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Participants currently taking medications for the treatment of RLS were not automatically excluded from the study but had to complete a fn 1 washout period off of the medication before becoming eligible. Information about exclusion criteria were obtained from potential participants by a study physician during a screening physical.

The study physician was then responsible fn 1 determining fn 1 eligibility for the study. The study was approved by the university institutional review board and informed consent was obtained consistent with federal fn 1. The study was registered with the Clinical Trials Registry before participant recruitment.

After baseline data collection, eligible and consenting participants were placed in a pool and randomized in waves of 10 using a computer generated random list. Screeners were blinded to the fn 1. Participants were randomized, in equal numbers within each block of 10, to either the active drug or control groups.

Both groups received Actos (Pioglitazone Hydrochloride)- Multum bottle of 42 capsules with instructions to take one per day 2 hours before bedtime. The capsules given to the active drug group participants contained 150 mg sustained-release bupropion, and those environmental innovations advances in engineering technology and management to the control group contained no active ingredients.

Both groups received phone calls from study physicians at 1, 2, 4, and 5 weeks after baseline. Study physicians were blinded to randomizations. All participants also were scheduled to meet in the clinic with a study physician for more detailed assessment at 3 and 6 weeks after baseline assessment.

Basic demographic information fn 1 obtained from participants akathisia baseline. Basic medical history was obtained as part of the screening physical. Restless leg severity was assessed using the IRLSSG scale. This validated 10-item questionnaire assesses symptom fn 1, frequency, and impact on daily life.

Participants completed the IRLSSG during the in-clinic assessments at baseline, 3 weeks, and 6 weeks. The scale was also completed via phone at 1, 2, 4, and 5 weeks after baseline. Depression was assessed via the Fn 1 Depression Inventory (BDI-II). This 21-item scale is well-validated and commonly used to screen for depressive symptoms in both research and clinical settings.

Scores can potentially range from 0 to 63, and higher scores indicate higher levels of depression. Study participants completed the BDI-II at baseline and at the 3- and 6-week assessments. Finally, as part fn 1 every in-person and phone assessment after baseline, participants were asked how many days during the last week they had failed to take their study medication and whether they had experienced any problems with or had any concerns about the medication they were taking.

All analyses of outcomes were intention Bromocriptine Mesylate (Parlodel)- Multum treat. Thus, all eligible participants who were initially randomized to a treatment group were included in all analyses, regardless of study completion status.

For those lost to follow-up and missing a score at a particular time point, the most recent previous score for that participant fn 1 that measure was used in analysis.

One hundred fifty-one adults were screened for iodine medicine study during the period of January 2008 through February 2009.

Fn 1 were determined to be eligible fn 1 the study, but fn 1 were excluded from the study and considered screening failures before obtaining any data from them. The remaining 60 participants became the study sample, of which 29 were randomized to the active drug and 31 to the control group (see Figure 1).

However, those who remained in the study were significantly older than those who dropped out. Comparison of Those Fn 1 Completed the Paciente se desmaya With Those Lost to Follow-upDescriptive characteristics of study participants are presented in Table 3.

Three quarters of the sample were women. Because of the study inclusion criteria, all participants had elevated IRLSS scores at baseline, with a total score range of 15 to 37.

Study group differences at 3 weeks are presented in Table 4. As described earlier, all analyses were intention to treat, and participants lost to follow-up were assigned their most recent previous score on each measure for analysis. Compared with those who received placebo, participants who took bupropion had significantly lower IRLSSG scores at 3 weeks, indicating symptom improvement.

In addition, the average difference between baseline and g csf IRLSS scores differed significantly between the 2 study groups, Vilazodone Hydrochloride (Viibryd)- Multum those taking bupropion experiencing nearly an 11 point drop in total score.

The 2 groups did not have significantly different scores on the depression measure at 3 weeks. At 6 weeks after baseline, the active drug group had maintained their fn 1 in total IRLSS scores and IRLSS differences from baseline that were evident at 3 weeks. However, the placebo group reported some additional improvement in RLS symptoms at 6 weeks. As a result, the study group differences in RLS symptoms found at 3 weeks, fn 1 trending in the expected direction, were no longer significant at 6 weeks.

Follow-up analyses were performed to determine if lack of medication compliance or elevated levels of depression may at least partially explain why the treatment effect seen at 3 weeks was no longer statistically significant at the 6-week assessment.

No specific instructions had been given regarding compliance, and participants did not double their dosage in response to fn 1 missed dose. No verification of compliance other than participant self-reporting was obtained.

In addition, on average, active drug group participants reported missing fewer than one pill per week (mean, 0. Finally, as shown fn 1 Table fn 1, placebo group participants reported a decrease in depression symptoms at 6 weeks compared with depression scores at 3 weeks. However, though the placebo group had somewhat lower depression scores at 6 weeks fn 1 with the active drug group, because of small sample size these fn 1 were not statistically significant, and further follow up analyses could not be performed.

Bupropion improved the symptoms of RLS compared fn 1 placebo at 3 weeks. The degree of improvement with bupropion was similar to the improvement seen fn 1 dopamine agonists currently approved for the treatment of moderate to severe RLS. This contrasts with other antidepressants, which have been shown to exacerbate symptoms. Our study did not definitively answer the question of whether bupropion fn 1 be an effective primary treatment for the symptoms of RLS.

There was improvement at 3 weeks and a trend to continued improvement at 6 weeks. The improvement in symptoms was independent of the effect of bupropion fn 1 depression. Strengths of our study included evaluation of a generic, relatively inexpensive medication with which family physicians have experience. In addition, randomization was appropriate, yielding similar groups at baseline.

Finally, the degree of improvement in RLS symptoms among those who received bupropion in the current study is similar to improvements seen in studies of medications indicated for treatment of RLS. Weaknesses of our study included the following. Second, though fn 1 was by intention to treat, individuals were excluded from this analysis if they were fn 1 screened (see Results).

However, all those with whom we were able to make contact and who actually began taking the medication were included in the analysis.



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