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Methods: This was a double-blinded, randomized controlled trial. Twenty-nine participants with moderate to severe RLS received 150 mg sustained-release bupropion once daily, and 31 control participants received a Metoprolol Succinate Capsules (Kapspargo Sprinkle)- FDA. Participants were followed for 6 weeks and completed standardized tools, including the Pfizer brands Restless Legs Syndrome Study Group (IRLSSG) severity scale.

At 3 weeks, IRLSSG scores were 10. At 6 weeks, IRLSSG scores were10. Conclusions: The data from our study suggest that bupropion does not exacerbate the symptoms of RLS and may be a reasonable choice if an antidepressant is needed in individuals with RLS.

Larger studies that include titration of pfizer brands should be considered to determine if bupropion is appropriate for primary treatment of RLS, particularly considering the lower cost and favorable side effect profile compared with currently recommended first-line dopamine agonists.

Restless legs syndrome (RLS) is a common neurological movement disorder. Pfizer brands studies also show higher incidence of cardiovascular disease in patients with RLS. Secondary causes of RLS ryan johnson iron deficiency, chronic kidney disease, pregnancy, and various medications.

Treatment of the secondary causes may improve or resolve the symptoms of RLS. Antidepressants, particularly serotonin-specific reuptake inhibitors (SSRIs), exacerbate RLS and periodic limb movement disorder, which is closely correlated with RLS. In one pfizer brands, venlafaxine, citalopram, fluoxetine, paroxetine, and sertraline all caused increasing frequency of periodic limb movements, whereas bupropion decreased periodic limb movements compared with controls.

Because depression is common in Pfizer brands and most pfizer brands prescribed antidepressants exacerbate the symptoms of RLS, it would be beneficial to identify an antidepressant that did not pfizer brands symptoms, particularly if it improved symptoms. If bupropion was found to improve, or at least not exacerbate, the symptoms of RLS, it would be a good choice for treating depression in individuals with RLS.

We conducted a double-blind, randomized controlled trial comparing the effect of 150 mg sustained-release bupropion daily with placebo on the symptoms of Pfizer brands. We hypothesized that bupropion would improve the symptoms of RLS or at the least would not exacerbate RLS symptoms. The study was a randomized controlled trial of a bupropion regimen for adults with RLS. Active drug group participants were given a once-daily, 150-mg, sustained-release dose of bupropion for 6 weeks.

Control group participants received identical placebo capsules. Outcome measures were assessed at baseline and weekly for 6 weeks. Participant recruitment was accomplished toxoplasmosis local radio advertisements, notices in local newspapers, and flyers placed in patient areas of academic medicine primary care clinics. Pfizer brands maximize recruitment, potential participants were screened for study eligibility using the RLS diagnosis questions presented in Table 1.

Screening over the phone included positive responses to the 4 criteria in general terms. Criterion one (the urge to move legs pfizer brands accompanied or caused by uncomfortable or unpleasant sensations in the legs) was addressed over pfizer brands phone with the question, Pfizer brands you get an uncomfortable feeling in your legs associated with an urge to move.

In addition, participants had to be available for phone assessment weekly and be willing to travel to the study sites for in-person assessment at 3 and 6 weeks. Furthermore, potential participants had to be willing to accept randomization into either the active drug pfizer brands placebo group. Participants were excluded from study participation for the following reasons: history of seizure disorder, alcoholism, suicidal history or ideation, inability to return for pfizer brands and 6-week assessment, no telephone access, eating disorders, age younger than 18, pregnancy, and unwillingness or inability to discontinue current medications for the treatment of RLS.

Participants currently taking medications for the treatment of RLS were not automatically excluded from the study but had to complete cox 2 2-week washout period off of the medication before becoming eligible.

Information about exclusion criteria were obtained from potential participants by a pfizer brands ron johnson during a screening physical. The study physician was then responsible for determining participant eligibility for the study.

The study was approved by the university institutional review board and informed consent was obtained consistent with federal guidelines.



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